Participate in a Clinical Trial

Choosing to participate in a T1D clinical trial is a very personal decision, but one that can have a significant impact on curing, preventing and treating T1D. There are many opportunities in the Greater New York Metro area and virtually to participate in a T1D clinical trial close to home. See below for active opportunities!

Breakthrough T1D has an easy-to-use tool called the Clinical Trials Connection where you can match with a clinical trial in 60 seconds. It asks users some simple questions about themselves before matching them with trials for which they are eligible. Clinical Trials Connection uses your city, distance you’re willing to travel and other characteristics to narrow down hundreds of trials to the ones in which you might be interested. Start your search by visiting breakthrought1d.org/impact/research/clinical-trials today!

FEATURED T1D STUDIES IN
GREATER NEW YORK

CHORD1

The purpose of this study is to investigate why individuals with type 1 diabetes remain at increased risk for heart disease and stroke, even after the reduction of their “bad” LDL-cholesterol.

Who is eligible

• Who are ≥ 18 years old
• Who have been diagnosed with type 1 diabetes
• Who also have an LDL-cholesterol ≥ 100mg/dL

DESIGNATE

The goal of this study is to see how the experimental study drug, siplizumab, can block or weaken the cells that attack beta cells in the pancreas. This would allow the beta cells to continue to function and produce insulin.

Who is eligible

• Between the ages of 18 and 45
• Have been diagnosed with type 1 diabetes within the last 18 months
• Are in good general health

DESIGNATE is active, but not currently enrolling participants

DIAGNODE-3

DIAGNODE-3 is a Breakthrough T1D-funded phase 3 clinical trial of the disease-modifying therapy Diamyd®. The goal is to preserve as many healthy beta cells as possible to maintain the body’s own insulin production.

Who is eligible

• Between the ages of 12-28
• Have been diagnosed with stage 3 type 1 diabetes within the last 6 months
• Tested positive for a specific genetic marker (HLA DR3-DQ2)

View our Breakthrough T1D article covering this study HERE!

THE PROMISE STUDY 
Is your family expecting? Join Mount Sinai (NYC) in The Promise Study.

• Are you pregnant with type 1 diabetes?
• Are you an expectant father with type 1 diabetes?
• Are you an expectant parent with a child who has type 1 diabetes?

JAKPOT T1D
TrialNet is testing two different Janus kinase (JAK) inhibitors to see if either or both can preserve insulin production in people recently diagnosed with type 1 diabetes (T1D).

This study is enrolling people who are:

• Age 12-35
• Newly diagnosed with T1D (in past 3 months)
• Up to date on required vaccines (including the flu vaccine when it is available)
• Not pregnant, breastfeeding or planning to become pregnant while in the study
• AND have:
  • One or more diabetes-related autoantibodies
  • Hemoglobin A1C below 10%
  • C-peptide detectable during a mixed-meal tolerance test (MMTT)

T1D RELAY
TrialNet is studying the use of rituximab-pvvr and abatacept, one after the other, to learn if using both treatments extends insulin production in people newly diagnosed with type 1 diabetes (T1D).

This study is enrolling children and adults who are:

• Age 8-45
• Newly diagnosed with T1D (in past 3 months)
• Up to date on required vaccines (including the flu vaccine when it is available)
• Not pregnant, breastfeeding or planning to become pregnant while in the study
• AND have:
  • 1 or more diabetes-related autoantibodies
  • C-peptide detectable during a mixed-meal tolerance test (MMTT)

TRIALNET

This study is screening relatives of type 1 diabetes for the antibodies associated with a higher risk of developing type 1 diabetes. Autoantibodies are a sign that the immune system may be attacking the insulin-producing cells in the pancreas.

Who is eligible:

• People 2 years 6 months of age to 45 years of age and have a brother, sister, child, or parent with type 1 diabetes.
• People 2 years 6 months of age to 20 years of age and have a cousin, aunt, uncle, niece, nephew, half-sibling, or grandchild with type 1 diabetes.

Time Commitment:

One-time blood test: Capillary (finger-prick) or Venipuncture (blood draw). If tested positive, followed up annually or semi-annually until progression to Stage 3 T1D

Virtual Studies

Diabetes Technology Use in U.S. Hospitals: A Survey of Patient Experiences

Stanford Medicine wants to hear from you, if you live with diabetes and visited a hospital or emergency room in the past year.

Don’t have much experience with diabetes technology? Stanford Medicine still wants to hear from you!

Please complete the survey linked above to participate in their research.

T1DAL Study

Are you a teen with T1D? Do you want to learn how to live a healthier lifestyle? Consider joining TIDAL!

T1DAL stands for Type 1 Diabetes Adolescents for healthier Lifestyles. T1DAL was designed to support teens in living their healthiest and happiest lives with T1D.

This is a virtual, group-based program led by Brown University. You’ll be invited to attend one 60-minute session per week for about 4 months and a few individual check-in calls with a trained study staff member.

Interested? Fill out the interest form here: T1DAL Study.

If you have any questions, please contact our Greater New York Metro Chapter Clinical Trials Education Volunteer, Alecia Wesner.

Updated: March 5, 2025