ViaCyte, a beta cell replacement company long supported by Breakthrough T1D, and CRISPR Therapeutics have a new first: Gene-editing for type 1 diabetes (T1D). By the end of the year, they will start a clinical trial of VCTX210, a gene-edited stem cell replacement therapy for this disease. Combining ViaCyte’s leading stem cell capabilities, which were developed with significant support from Breakthrough T1D, with CRISPR Therapeutics’ pre-eminent gene-editing platform, has significant potential in the development of a cell replacement therapy that does not require immune suppression, advancing ViaCyte’s mission of providing a cure for diabetes and Breakthrough T1D’s vision of a world without T1D.
“Breakthrough T1D applauds ViaCyte and CRISPR for bringing their VCTX210 therapy into human clinical trials. This is an enormous step forward in alignment with Breakthrough T1D’s vision to bring insulin independence to people with type 1 diabetes without the need for immunosuppression,” says Sanjoy Dutta, Ph.D., Breakthrough T1D Vice President of Research. “Breakthrough T1D is proud of the work we have done with ViaCyte over the past 10+ years that has led to this transformative step and looks forward to forthcoming results.”
The phase I clinical trial to evaluate the safety, efficacy, and immune evasiveness of the therapy will begin in Canada this year.
Breakthrough T1D Leadership: Breakthrough T1D has been a long-time and significant supporter of ViaCyte, supporting the company through research funding, as well as advocating for government funding for the California Institute of Regenerative Medicine, which also supported ViaCyte. Our funding 15 years ago (when ViaCyte was called CyThera) underwrote development of the proprietary line of precursor stem cells used in their treatment. Breakthrough T1D also funded the preclinical and clinical studies of ViaCyte’s PEC-01™ therapies, which are designed to mature into islet tissue in humans, including glucose-responsive insulin-secreting beta cells. This includes the first ever clinical trial to test a stem cell-derived cell replacement therapy for T1D, in 2014.
This funding is one of several approaches to cell replacement Breakthrough T1D has advanced through research funding as part of the Breakthrough T1D Cell Replacement Consortium. Visit here to find out more about our program.
